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Ralph M. Steinman (Ralph Marvin Steinman) was born on 14 January, 1943 in Montreal, Quebec, Canada, is a Canadian immunologist and cell biologist. Discover Ralph M. Steinman's Biography, Age, Height, Physical Stats, Dating/Affairs, Family and career updates. Learn How rich is he in this year and how he spends money? Also learn how he earned most of networth at the age of 68 years old?

Popular As Ralph Marvin Steinman
Occupation N/A
Age 68 years old
Zodiac Sign Capricorn
Born 14 January, 1943
Birthday 14 January
Birthplace Montreal, Quebec, Canada
Date of death 30 September, 2011
Died Place Manhattan, New York, U.S.
Nationality Canada

We recommend you to check the complete list of Famous People born on 14 January. He is a member of famous with the age 68 years old group.

Ralph M. Steinman Height, Weight & Measurements

At 68 years old, Ralph M. Steinman height not available right now. We will update Ralph M. Steinman's Height, weight, Body Measurements, Eye Color, Hair Color, Shoe & Dress size soon as possible.

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Who Is Ralph M. Steinman's Wife?

His wife is Claudia Hoeffel (3 children)

Family
Parents Not Available
Wife Claudia Hoeffel (3 children)
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Ralph M. Steinman Net Worth

His net worth has been growing significantly in 2023-2024. So, how much is Ralph M. Steinman worth at the age of 68 years old? Ralph M. Steinman’s income source is mostly from being a successful . He is from Canada. We have estimated Ralph M. Steinman's net worth, money, salary, income, and assets.

Net Worth in 2024 $1 Million - $5 Million
Salary in 2024 Under Review
Net Worth in 2023 Pending
Salary in 2023 Under Review
House Not Available
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1943

Ralph Marvin Steinman (January 14, 1943 – September 30, 2011) was a Canadian-American physician and medical researcher at Rockefeller University, who in 1973 discovered and named dendritic cells while working as a postdoctoral fellow in the laboratory of Zanvil A. Cohn, also at Rockefeller University.

1968

He received a bachelor of science degree from McGill University and received his M.D. (magna cum laude) in 1968 from Harvard Medical School.

He completed his internship and residency at Massachusetts General Hospital.

1995

Ralph Steinman was born into an Ashkenazi Jewish family in Montreal, one of four children of Irving Steinman (d. 1995), a haberdasher, and Nettie Steinman (née Takefman, 1917–2016).

The family soon moved to Sherbrooke, where the father opened and ran a small clothing store "Mozart's".

After graduating from Sherbrooke High School, Steinman moved back to Montreal, where he stayed with his maternal grandparents Nathan and Eva Takefman.

2002

In addition, he was made a member of Institute of Medicine (U.S.; elected 2002) and the National Academy of Sciences (U.S.; elected 2001).

2007

Steinman had received numerous other awards and recognitions for his lifelong work on dendritic cells, such as the Albert Lasker Award For Basic Medical Research (2007), the Gairdner Foundation International Award (2003), and the Cancer Research Institute William B. Coley Award (1998).

2011

Steinman was one of the recipients of the 2011 Nobel Prize in Physiology or Medicine.

On October 3, 2011, the Nobel Committee for Physiology or Medicine announced that he had received one-half of the Nobel Prize in Physiology or Medicine, for "his discovery of the dendritic cell and its role in adaptive immunity".

The other half went to Bruce Beutler and Jules A. Hoffmann, for "their discoveries concerning the activation of innate immunity".

However, the committee was not aware that he had died three days earlier, on September 30, from pancreatic cancer.

This created a complication, since the statutes of the Nobel Foundation stipulate that the prize is not to be awarded posthumously.

After deliberation, the committee decided that as the decision to award the prize "was made in good faith", it would remain unchanged, and the prize would be awarded.

Steinman's daughter said that he had joked the previous week with his family about staying alive until the prize announcement.

Steinman said: "I know I have got to hold out for that. They don't give it to you if you have passed away. I got to hold out for that."

2016

In 2016, the city of Sherbrooke, Quebec, where Steinman lived during his childhood, named a new street rue Ralph Steinman, in honor of the only Sherbrooke native ever to win a Nobel Prize.

Immunology tries to understand resistance to infection.

Infections are first resisted by innate immunity, followed by adaptive immunity, which has memory, so can prevent reinfection.

Two questions that immunologists ask: 1) By what mechanisms do innate and adaptive resistance come about? 2) How do these mechanisms contribute to other fields of medicine such as cancer, allergy, autoimmunity, etc.?

In the 20th century, two theories arose: 1) Macrophages contribute to innate resistance through phagocytosis and intracellular killing 2) Antibodies mediate adaptive resistance by neutralizing microbial toxins.

Steinman discovered that dendritic cells link innate to adaptive immunity, including adaptive T cell-mediated immunity.

He studied the initiation of antibody responses in tissue culture in the laboratory.

As shown, he found out that antigens, lymphocytes, and "accessory cells" together create immune responses.

Accessory cells contain a new cell type with probing cell process or "dendrites".

These cells proved to be The Missing Link between innate and adaptive immunity.

Several features were used to identify and purify dendritic cells from mouse spleen.

Because dendritic cells were discovered among "adherent" accessory cells (i.e. those that attach to tissue culture surfaces), they had to be distinguished from macrophages, whose hallmarks were persistent phagocytosis and adherence to tissue culture surfaces.

However, Steinman found that dendritic cells had a different morphology and expressed different molecules from macrophages.

For example, they did not express FcR- receptors, but did express major components of the major histocompatibility complex II and did not adhere to surfaces or exploit phagocytosis.

Macrophages, though, showed the opposite characteristics.

The study was carried out in collaboration with Zanvil A. Cohn, who studied resistance to infectious diseases, especially the biology of macrophages.

Some general features of T cell responses that are initiated by dendritic cells (DCs):

DCs capture, process and present antigens: