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Meinrad Busslinger was born on 30 July, 1952 in Gebenstorf, is an A 21st-century biochemist. Discover Meinrad Busslinger's Biography, Age, Height, Physical Stats, Dating/Affairs, Family and career updates. Learn How rich is he in this year and how he spends money? Also learn how he earned most of networth at the age of 71 years old?

Popular As Meinrad Busslinger
Occupation N/A
Age 71 years old
Zodiac Sign Leo
Born 30 July, 1952
Birthday 30 July
Birthplace Gebenstorf
Nationality Switzerland

We recommend you to check the complete list of Famous People born on 30 July. He is a member of famous with the age 71 years old group.

Meinrad Busslinger Height, Weight & Measurements

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Meinrad Busslinger Net Worth

His net worth has been growing significantly in 2023-2024. So, how much is Meinrad Busslinger worth at the age of 71 years old? Meinrad Busslinger’s income source is mostly from being a successful . He is from Switzerland. We have estimated Meinrad Busslinger's net worth, money, salary, income, and assets.

Net Worth in 2024 $1 Million - $5 Million
Salary in 2024 Under Review
Net Worth in 2023 Pending
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Timeline

1952

Meinrad Busslinger (born 30 July 1952 in Gebenstorf, Switzerland ) is a biochemist and immunologist, renown for his work on B cells.

He is a Senior Scientist and Scientific Deputy Director of the Research Institute of Molecular Pathology (IMP) in Vienna, Austria.

Meinrad Busslinger grew up in the Swiss town of Zug, near Zurich, where he obtained his grammar school education.

1972

From 1972 to 1976, he studied natural sciences at the Swiss Federal Institute of Technology (ETH) in Zurich, where he majored in biochemistry.

1976

During his PhD studies (1976-1981), Busslinger discovered important regulatory elements involved in the transcriptional control of gene expression by investigating the regulation of sea urchin histone genes.

1981

He performed his PhD work under the supervision of Max L. Birnstiel at the University of Zurich, from where he received a PhD degree in molecular biology in 1981.

In 1981, Busslinger joined the lab of Richard A. Flavell at the MRC Institute Mill Hill in London as a postdoctoral fellow.

There, he discovered that a single nucleotide mutation in the first intron of the β-globin gene causes β+-thalassemia and that DNA methylation of promoter sequences prevents gene transcription.

1983

In 1983, Busslinger became a Group Leader at the Institute of Molecular Biology II of the University of Zurich.

Here, he discovered a new set of histone genes of the sea urchin and identified a tissue-specific transcription factor (TSAP) as an essential regulator of these genes, which later turned out to be a member of the Paired box (Pax)-containing transcription factor family.

1987

In 1987, Max Birnstiel recruited Busslinger to join the newly founded Research Institute of Molecular Pathology (IMP) in Vienna, Austria, as one of the first Senior Scientists.

1996

In 1996, Busslinger was appointed Professor at the University of Vienna.

1999

In 1999, Busslinger and his lab described the first molecular definition of a lineage commitment process by identifying Pax5 as the B cell lineage commitment factor that restricts the developmental options of early lymphoid progenitors to the B cell pathway by repressing lineage-inappropriate genes and that simultaneously promotes B cell development by activating B-cell-specific genes.

To date, Pax5 is known to function as a guardian of B cell identity for early to late B cell development and to function as an important tumor suppressor or oncoprotein in B cell leukemia.

In addition to Pax5, the Busslinger group investigated the role of other important transcription factors, such as E2A, EBF1, Ikaros, and Blimp1, in regulating distinct aspects of B cell development and immunity.

Busslinger also contributed to the current knowledge of how the large locus encoding the immunoglobulin heavy chain (IgH) protein undergoes spatial contraction by looping in Early B cell development.

This long-range looping induces the juxtaposition of Variable (V) gene segments next to Diversity (D) gene segments, which facilitates V-to-DJ recombination to generate a functional IgH gene.

Busslinger identified Pax5 as a critical regulator of IgH locus contraction that facilitates chromatin loop extrusion across the entire locus.

He is a member of the Editorial Board for Immunity.

2007

In 2007, he became the IMP's Director of Academic Affairs and, in 2013, Scientific Deputy Director.

At the IMP, Busslinger changed his research focus from sea urchin embryogenesis to B cell immunology, which was promoted by the identification of a B-cell-specific transcription factor as a mammalian homologue of the sea urchin regulator TSAP.

Protein purification and sequencing identified the B-cell-specific transcription factor as Pax5, and gene inactivation in the mouse defined Pax5 an essential regulator of B cell development.