Frank Westheimer

Frank Henry Westheimer (January 15, 1912 – April 14, 2007) was an American chemist.

Frank Henry Westheimer was born on January 15, 1912, to Henry F. Westheimer (1870–1960) and Carrie C (Burgunder) Westheimer (1887–1972) of Baltimore, Maryland.

He graduated from Dartmouth College in 1932.

He went on to Harvard University, where he earned his masters in chemistry in 1933 and his doctorate in chemistry in 1935.

Westheimer came to Harvard hoping to do research with James Bryant Conant.

When told that Conant would not take on new students, Westheimer outwaited him and was finally accepted as his last graduate student.

Westheimer did some work on semicarbazone at Conant's suggestion.

Conant also suggested that Westheimer work during the summer with Alsoph Corwin at Johns Hopkins University.

By doing porphyrin synthesis with Corwin, Westheimer gained needed laboratory experience.

In 1933, Conant became president of Harvard in 1933 and ceased doing research.

Nonetheless, Conant's interactions with Westheimer had a lasting effect, impressing Westheimer with the need "to do important things".

"'The notion that Conant essentially was saying, 'Well, that problem is all right, but good God, you can do better,' was very important to me. From then on, I tried to ask myself about problems, whether they were really worth the investment of time.'"

Westheimer completed his Ph.D. with E.P. Kohler.

Although Westheimer described Kohler's organic chemistry class as "marvelous", Kohler gave Westheimer little direction or feedback about his research, which was largely self-directed.

Another of Kohler's students, Max Tishler, expanded upon some of Westheimer's research, leading to a co-publication on the derivation of a furanol.

In 1935 and 1936, as a National Research Council Fellow, Westheimer worked with physical chemist Louis P. Hammett at Columbia University.

Hammett was a founder of the field of physical organic chemistry.

He taught at the University of Chicago from 1936 to 1954, and at Harvard University from 1953 to 1983, becoming the Morris Loeb Professor of Chemistry in 1960, and Professor Emeritus in 1983.

Westheimer taught at the University of Chicago from 1936 to 1954, and at Harvard University from 1953 to 1983.

Westheimer's first academic appointment was an independent Research Associateship at the University of Chicago, from 1936 to 1937.

He became an instructor in 1937 and a Professor in 1948.

As a lecturer in chemistry he taught the university's first course in physical organic chemistry.

During Westheimer's second year at Chicago, John Gamble Kirkwood taught there.

Westheimer worked with Kirkwood on problems in organic chemistry involving electrostatics.

Westheimer related electrostatics to their effects on the properties of organic compounds.

Kirkwood and Westheimer published four classical papers developing fundamental ideas in enzymology about the theory of the electrostatic influence of substituents on the dissociation constants of organic acids.

They developed a Bjerrum electrostatic analysis of carboxylic acids.

He served as chairman of the chemistry department at Harvard from 1959 to 1962.

He became the Morris Loeb Professor of Chemistry at Harvard in 1960.

He retired from teaching to become Professor Emeritus in 1983, and retired from research in 1988.

He received the National Medal of Science in 1986 "For his series of extraordinary, original and penetrating investigations of the mechanisms of organic and enzymic reactions, which have played an unequaled role in the advancement of our knowledge of the ways in which chemical and biochemical processes proceed."

The Westheimer medal was established in his honor in 2002.

Westheimer did pioneering work in physical organic chemistry,

applying techniques from physical to organic chemistry and integrating the two fields.

He explored the mechanisms of chemical and enzymatic reactions,

and made fundamental theoretical advances.

Westheimer worked with John Gamble Kirkwood on the Bjerrum electrostatic analysis of carboxylic acids;

with Joseph Edward Mayer on the calculation of molecular mechanics;

explored the mechanisms of enzyme catalysis with Birgit Vennesland

and determined the mechanisms of chromic acid oxidations and kinetic isotope effects.