Age, Biography and Wiki
Fionula Brennan was born on 1957 in Manorhamilton, Ireland, is an Irish immunologist (1957–2012). Discover Fionula Brennan's Biography, Age, Height, Physical Stats, Dating/Affairs, Family and career updates. Learn How rich is she in this year and how she spends money? Also learn how she earned most of networth at the age of 55 years old?
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55 years old |
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1957 |
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Manorhamilton, Ireland |
Date of death |
15 June, 2012 |
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Ireland
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She is a member of famous with the age 55 years old group.
Fionula Brennan Height, Weight & Measurements
At 55 years old, Fionula Brennan height not available right now. We will update Fionula Brennan's Height, weight, Body Measurements, Eye Color, Hair Color, Shoe & Dress size soon as possible.
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She is currently single. She is not dating anyone. We don't have much information about She's past relationship and any previous engaged. According to our Database, She has no children.
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Fionula Brennan Net Worth
Her net worth has been growing significantly in 2023-2024. So, how much is Fionula Brennan worth at the age of 55 years old? Fionula Brennan’s income source is mostly from being a successful . She is from Ireland. We have estimated Fionula Brennan's net worth, money, salary, income, and assets.
Net Worth in 2024 |
$1 Million - $5 Million |
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Pending |
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Under Review |
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Timeline
Fionula Brennan (1957–2012) was an Irish immunologist and Professor of Cytokine Immunopathology at the Kennedy Institute of Rheumatology.
Brennan described the role of tumour necrosis factor (TNF) in rheumatoid arthritis by demonstrating that anti-TNF antibodies inhibit inflammation of the synovial joints.
This research led directly to the development of anti-TNF therapy.
Fionula Brennan was born in Manorhamilton, County Leitrim, to Josie and Ted Brennan in 1957.
She had a brother and a sister.
Brennan received her undergraduate degree and PhD in immunology from the University of Bristol.
From the late 1980s, Brennan worked at the Kennedy Institute of Rheumatology, where her work enabled revolutions in the treatment of rheumatoid arthritis.
In the late 1980s, developments in knowledge about cytokine production and methods of study had made it possible to investigate further their role in rheumatoid arthritis.
Since it remained unclear which cytokine should be targeted to produce therapeutic effects, they were not investigated as therapeutic targets.
This group developed out of the 1987 TNF meeting and brought together researchers that worked in different fields such as cancer research and infections and inflammatory disease.
However, as a postdoctoral researcher working initially with Ravinder Maini and then under Marc Feldmann from 1988 to 1989, Brennan questioned whether it was possible to suppress pathologic TNF selectively.
Her work developed upon that of Feldmann and Glenn Buchan.
Brennan's experiments analysed cytokine expression in a dissociated synovial cell culture model, which kept immune/inflammatory cells alive and made it possible to study disregulation.
Brennan's experiments provided the first evidence that TNF might be a therapeutic target.
Brennan's work showed that rheumatoid mixed synovial cell cultures were distinct from osteoarthritic cell cultures because anti-TNF antibodies reduced production of IL-1 cytokines, which regulate immune and inflammatory responses.
Later experiments showed that it also downregulated other proinflammatory cytokines (GM-CSF, IL-6, and IL-8).
This unexpected "TNF-dependent cytokine cascade" suggested that TNF might be a therapeutic target for rheumatoid arthritis.
Brennan spent the rest of her career building upon her significant early findings the importance of TNF overproduction in rheumatoid arthritis.
She challenged the idea that T-cells were not relevant to rheumatoid arthritis by showing that TNF was produced by T-cell activated macrophages.
Brennan's final project sought to understand why regulatory T-cells failed to affect disease process.
She found that pathogenic T-cells in joints and cytokine activated T-cells were not controlled by regulatory T-cells.
Brennan and Frances Balkwill ran the British Cytokine Group (BCG) for around 10 years.
Brennan was Professor of Cytokine Immunopathology at the Kennedy Institute of Rheumatology until 2011.
Brennan died on 15 June 2012 at Parkside Hospital, Wimbledon, as a result of cancer.
She was survived by her husband Paul Gallagher and children Ciarán and Bridget.
The Marc and Tania Feldmann Charitable Trust plan to commemorate Brennan by naming a grant in her honour.