Anne Spang

Anne Spang (born 29 November 1967 in Wadern) is a German Biochemist/Cell Biologist and Professor at the Biozentrum University of Basel, Switzerland.

Anne Spang studied Chemical Engineering at the University of Applied Sciences in Darmstadt and Biochemistry at the University of Paris VI, France.

She received her PhD in 1996 at the Max-Planck Institute of Biochemistry in Martinsried.

She was then a postdoctoral fellow at the University of California, Berkeley, USA.

From 1999 to 2006 she was an Independent Research Group Leader at the Friedrich Miescher Laboratory of the Max Planck Society in Tübingen.

Since 2005 Anne Spang has held the position of Professor of Biochemistry and Cell Biology at the Biozentrum University of Basel.

Anne Spang investigates the basics of intracellular transport.

Spang gained an international reputation through her discovery of the maturation process from early to late endosomes.

In the nematode, Caenorhabditis elegans, she has identified the evolutionary conserved SAND-1 protein, which serves as the switch in Rab conversion during the maturation process.

In addition, her research has shown that ArfGAP proteins are important for the uptake of cargo into transport vesicles and that the small GTPase Arf1 and COPI components play a role in mRNA transport and mRNA metabolism.

Her research findings are significant for the understanding of many diseases which are based on the location of defects in protein and mRNA in the cell, such as cystic fibrosis and lysosomal storage disorders.