Michel Ter-Pogossian

Michel Matthew Ter-Pogossian (April 21, 1925 – June 19, 1996) was an American medical physicist.

He was professor of radiology at the Washington University School of Medicine for over 30 years.

A pioneer in nuclear medicine, he is best known for his research on the positron emission tomography (PET).

He is considered one of its creators and often referred to as the "father of PET."

Ter-Pogossian was born on April 21, 1925, in Berlin to Armenian parents from the Ottoman Empire that escaped the Armenian genocide.

He was the only child.

His family later moved to France, where Ter-Pogossian grew up.

He developed an early interest in science and experimented with toy physics and chemistry kits as a child.

Ter-Pogossian attended the University of Paris, from which he received his bachelor's degree in mathematics in 1942 or 1943.

He subsequently studied at the Institute of Radium under Irène Joliot-Curie, graduating in 1946.

He was active in the French Resistance during World War II.

Ter-Pogossian moved to the United States in 1946 to complete his studies.

He preferred the US over Britain because the former seemed "more exciting."

He enrolled at Washington University in St. Louis as a graduate student in 1946.

He was drawn to the university by and studied under Arthur Compton, who was also the university's chancellor at the time.

He simultaneously worked in the physics department as a research assistant.

Ter-Pogossian received his master's degree in 1948, and his Ph.D. in nuclear physics from Washington University in 1950.

He joined the Mallinckrodt Institute of Radiology at Washington University in 1950.

In the same year he also joined the faculty of Washington University School of Medicine as an instructor in radiation physics.

In the mid-1950s he "reported the first biomedical application of a sodium iodide detector for the diagnosis and localization of intracranial tumors."

Ter-Pogossian was a pioneer in the use of cyclotron-produced radioactive tracers.

He is best known for his work on the positron emission tomography (PET).

His research began in the 1950s with a series of experiments that made PET a "practical diagnostic tool" by the 1970s.

In 1951 Ter-Pogossian developed a pioneering scanner that detected radioactivity concentrations in living material.

He was named professor of radiation physics in 1961, professor of biophysics in physiology in 1964, and professor of radiation sciences in 1973.

Between 1963 and 1991 Ter-Pogossian served as director of the division of radiation sciences at the Mallinckrodt Institute.

His early work led to the installation of a small biomedical cyclotron in the basement at the Washington University Medical Center in 1963.

He persuaded several government agencies to support the research.

It was the first cyclotron in the US located in a medical center.

The cyclotron produced short-lived, positron-emitting radionuclides intended to be used to develop techniques for measuring regional cerebral blood flow, oxygen metabolism, blood volume, and glucose metabolism.

The first PET unit was created in 1974 by the group led by Ter-Pogossian.

A decade later, PET units of that design were "used in many medical centers throughout the world."

Ter-Pogossian is recognized to have "led the research that turned the positron emission tomography (PET) scanner from an intriguing concept to a medical tool used in hospitals and laboratories everywhere."

After resigning from administrative duties in 1990, Ter-Pogossian devoted all his time to research.

He was a self-proclaimed "research junkie".

He became emeritus professor in 1995.

Ter-Pogossian spent his entire professional career at Washington University's Mallinckrodt Institute of Radiology.

His research focused on "increasing the number of practical clinical applications of cerebral scanning."

His work resulted in improvement of medical imaging, radiation therapy, and brachytherapy.

He developed a new type of nuclear medicine gamma camera, known as the "Ter-Pogossian camera."