Ian Frazer

Ian Hector Frazer (born 6 January 1953) is a Scottish-born Australian immunologist, the founding CEO and Director of Research of the Translational Research Institute (Australia).

Frazer and Jian Zhou developed and patented the basic technology behind the HPV vaccine against cervical cancer at the University of Queensland.

Researchers at the National Cancer Institute, Georgetown University, and University of Rochester also contributed to the further development of the cervical cancer vaccine in parallel.

Frazer was born in Glasgow, Scotland.

His parents were medical scientists, and he was drawn to science from a young age.

Frazer attended Aberdeen private school Robert Gordon's College.

He chose to pursue medicine over an earlier interest in physics due to physics having fewer research opportunities, and he received his Bachelor of Science and Bachelor of Medicine and Bachelor of Surgery, at the University of Edinburgh in 1974 and 1977 respectively.

It was during this time that he met his wife Caroline, whom he married in 1976.

His 1978–79 residency was in the Edinburgh Eastern General Hospital, the Edinburgh Royal Infirmary and the Roodlands General Hospital in Haddington.

In 1980/81 Frazer immigrated to Melbourne after he was headhunted by Dr. Ian Mackay at the Walter and Eliza Hall Institute of Medical Research to research viral immunology.

In 1981 he discovered that the immunodeficiency afflicting homosexuals in San Francisco was also found in the gay men in his hepatitis B study, and in 1984 helped to confirm that HIV was a cause.

It was also found that another sexually transmitted virus was having a surprising effect: the human papilloma virus (HPV) infection seemed to be inducing precancerous cells.

In 1985 he moved to the University of Queensland as a Senior Lecturer, with the opportunity to establish his own research laboratory.

It was here in the Lions Human Immunology Laboratories he continued to research HPV in men, and contributed to HIV research.

During this time Frazer also taught at the university and ran diagnostic tests for the Princess Alexandra Hospital and received his Doctor of Medicine qualification in 1988.

On a 1989 sabbatical he met virologist Jian Zhou, and the two considered the problem of developing a vaccine for HPV – a virus that cannot be cultured without living tissue.

Frazer convinced Zhou to join him, and in 1990 they began to use molecular biology to synthesize particles in vitro that could mimic the virus.

In March 1991 Zhou's wife and fellow researcher, Xiao-Yi Sun, assembled by Zhou's instructions two proteins into a virus-like particle (VLP), resembling the HPV shell, from which HPV vaccine would ultimately be made.

The vaccine completely protects unexposed women against four HPV strains responsible for 70% of cervical cancers, which kill about 250,000 women annually.

Frazer and Zhou filed a provisional patent in June 1991 and began work on developing the vaccine within UQ.

To finance clinical trials, Australian medical company CSL, and later Merck, were sold partial patents.

Later in 1991 the research was presented at a US scientific meeting, and Frazer became Director of the Centre for Immunology and Cancer Research at the University of Queensland (later renamed The Diamantina Institute for Cancer, Immunology and Metabolic Medicine, where he held a personal chair as director).

After three years in design, Gardasil went into testing, and Frazer became a professor in the university's Department of Medicine.

Its U.S. application was filed on 19 January 1994, but claimed priority under a 20 July 1992 PCT filing to the date of an initial [AU] Australian patent application filed on 19 July 1991.

In 1998 Frazer completed the first human trials for Gardasil, and became an Australian citizen.

US.

Estimates of the contemporary global mortality rate have remained in the 190,000 to 300,000 range from 2000 to 2010.

(CSL has the exclusive license to sell Gardasil in New Zealand and Australia, Merck the license elsewhere.) GlaxoSmithKline independently used the same VLP-approach to develop Cervarix, under a later US patent, licensing Frazer's intellectual property in 2005.

In 2006 results from the four-year Phase III trials led to Australian and US regulatory approval.

Frazer's studies showed 100% efficacious protective immunity in HPV naïve women, but could not directly test protective immunity (against HPV exposure) in adolescent girls.

As a surrogate test, antibody titer levels in vaccinated 9 to 15-year-old girls was shown high enough to give them the same level of immunity as vaccinated women.

It has been suggested that one way to bring cheaper equivalent vaccines to market is to mandate a similar induced immune response.

Frazer administered the first official HPV-vaccination, and was made 2006 Queenslander of the Year and Australian of the Year.

The 2007 WHO progress report says that preventable cervical cancer "was responsible in 2005 for up to 500,000 new cases, and up to 257,000 deaths, more than 90% in low- and middle-income countries", but, "According to WHO’s projections, deaths from cervical cancer will rise to 320,000 in 2015 and to 435,000 in 2030" (p.4).

These projections may be little effected by vaccination programs (anyway unlikely on cost grounds) because "A reduction in cancer incidence and mortality might not be measurable before 10 to 30 years after the vaccine is introduced." (p.5).

Other estimates of the problem's scale are broadly in agreement:

In the 2007 resolution of their US patent lawsuit, Frazer's and Jian Zhou's heirs (Zhou, who died in 1999, was survived by his widow Xiao-Yi Sun and a son Andreas) world-wide rights to the fundamental VLP science, and Frazer's and Zhou's priority to invention of that fundamental VLP science, were both established.

7,476,389, titled "Papilloma Virus Vaccines", was granted to co-inventors Ian Frazer and Jian Zhou (posthumously) on 13 January 2009.

After 2009 reports of adverse Gardasil reactions, Frazer said "Apart from a very, very rare instance where you get an allergic reaction from the vaccine, which is about one in a million, there is nothing else that can be directly attributable to the vaccine."

Ian Frazer is one of the "most trusted" Australians, and some critics have accused Gardasil's advocates of exploiting patriotism to promote its rapid Australian release.