Garth L. Nicolson

Garth L. Nicolson (born October 1, 1943) is an American biochemist who made a landmark scientific model for cell membrane, known as the fluid mosaic model.

He is the founder of The Institute for Molecular Medicine at California, and he serves as the president, chief scientific officer and emeritus professor of molecular pathology.

He is also a conjoint professor in the Faculty of Science and Technology, University of Newcastle, Australia.

During the outbreak of the Gulf War syndrome, he was the leading authority on the study of the cause, treatment and prevention of the disease.

He was appointed chairman of the Medical-Scientific Panel for the Persian Gulf War Veterans Conference.

On suspicion of the bacterium that caused the disease as a product of biological warfare, he made extensive scientific investigations and served as authority to the United States House of Representatives.

For his service he was conferred honorary Colonel of the US Army Special Forces and honorary US Navy SEAL.

He graduated from the University of California, Los Angeles in 1965 with a major in chemistry.

He was a USPHS Predoctoral Fellow from 1967 to 1970.

He joined research in biochemistry at the University of California, San Diego, from where he earned his PhD in 1970.

During 1970–1971 he worked as senior research associate in the Armand Hammer Cancer Centre of the Cancer Council Laboratory at the Salk Institute for Biological Studies, La Jolla.

With S.J. Singer, Nicolson published a paper titled "The Fluid Mosaic Model of the Structure of Cell Membranes" in 1972, which is now regarded as a classic paper in cell biology.

With over 600 scientific papers, the majority of Nicolson's research is in cancer biology and cellular properties related to aging.

Nicolson was born in Los Angeles, California.

He became head of the Cancer Council Laboratory, as well as director of Electron Microscopy Laboratory in 1972.

They made a seminal model for the structure of cell membranes, which they named the Fluid Mosaic Model, and published in a 12-page paper in the February 18, 1972, issue of Science.

It was the first model in cell biology to be based on thermodynamics properties.

Earlier descriptions of the cell membrane had serious inconsistencies with observed properties of the lipid bilayer.

According to the Fluid Mosaic Model, in contrast to other models, the cell membrane is composed of a single lipid bilayer which is associated with two groups of proteins.

Peripheral proteins are located on the surface, while integral proteins are embedded the lipid layer.

The proteins are highly varied, thus, creating a mosaic pattern.

Majority of the membrane is composed of phospholipids, which exhibit fluidity like oil.

The phospholids are not just stationary, but are able to move, and the proteins can move in the fluid lipid layer.

These properties give the membrane flexibility.

The model turned out to be the foundation of modern understanding of cell membrane structure and functions.

Although its basic assumptions are still true, the dynamic nature has been underestimated, and more information have been incorporated with new discoveries.

In 1974 he took the chair of the department of cancer biology, the post he held till 1976.

In 1975 he was appointed professor in the Department of Developmental and Cell Biology at the University of California, Irvine.

In 1978 he additionally became professor in the department of physiology and biophysics at the College of Medicine, University of California, Irvine.

In 1980 he was conferred the post Florence M. Thomas Professor of Cancer Research at the University of Texas M. D. Anderson Cancer Center, Houston, where he worked for seven years.

Between 1980 and 1996 he was also professor at the Graduate School of Biomedical Sciences, the University of Texas Health Science Center; as well as David Bruton Jr. Chair in Cancer Research, professor and chairman of tumor biology at The University of Texas M. D. Anderson Cancer Center.

During 1981–1998 he was adjunct professor in the department of pathology at the school of veterinary medicine, Texas A & M University.

He was also professor in the department of pathology and laboratory medicine at the University of Texas Medical School from 1982 to 1998.

From 1989 to 1999 he was professor in the department of internal medicine at the University of Texas Medical School.

In 1996 he founded The Institute for Molecular Medicine at Huntington Beach in 1996.

He became its president, chief scientific officer and research professor of molecular pathology.

He also serves as professor of integrative medicine at Capitol University of Integrative Medicine.

Since 2003 he is also the conjoint professor in the faculty of science and technology at the University of Newcastle, Australia.

He is a founding editor of the editorial board of the Cancer and Metastasis Reviews.

While working as research associate at the Salk Institute for Biological Studies, Nicolson collaborated with S.J. Singer at the University of California, San Diego.